Programme

Overview: Mitochondria are emerging as key cellular mediators of radiation damage. In addition to their established role in energy production and metabolism, recent studies have shown that mitochondria participate in inflammation and immune response activation. This symposium offers a unique overview of: • The role of mitochondrial DNA and RNA in mediating the immunogenic response to radiation, focusing on a newly uncovered crosstalk between mitochondria and the nucleus. • The crucial connection between mitochondrial status, compensatory metabolic changes and cancer radioresistance, which offers new molecular targets for radiotherapy.

Overview: This symposium will cover image-guidance in particle therapy, with a main focus on proton therapy. First, an overview of x-ray based in-room imaging and relevant clinical examples will be presented, along with an outlook on the future. Second, in vivo imaging for treatment verification will be presented, including an overview of secondary particles and imaging technologies like prompt gamma and PET, but also recent technological developments, status of clinical studies, and potential use in adaptive radiotherapy. Third, recent developments within proton CT will be presented, along with recent research on evaluation in non-homogeneous phantoms and calibrations studies comparing proton CT with conventional CT. The symposium will end with the roadmap for clinical introduction of MR-integrated proton therapy, including updates from ongoing studies around the world, and an outlook on the expected clinical benefit of MR-integrated proton therapy.

Overview: Firstly, the RTT perspective of personalised radiotherapy is explained, in the context of head and neck treatment. The technological, medical, and social aspects of personalised treatment are assessed. Next, we shift focus to the palliative setting examining personalised radiation therapy for those patients presenting with metastatic spinal cord compression and bone metastasis. The supportive care options are presented as well as relevant treatment planning considerations. The third part of this session highlights radiomics in head and neck RT. Current, novel and emerging application of radiomics will be appraised. This talk will review lessons learned so far which will inform the future recommendations in relation to this technology.

Overview: Mini-Orals are presented at one of the sessions scheduled in the two mini-oral theatres near the exhibition. Each author will present a 4-slide PowerPoint orally for 4 minutes, followed by 3 minutes for discussion. Sessions will not be streamed but authors are invited to upload per-recordings for the online platform.

Overview: Mini-Orals are presented at one of the sessions scheduled in the two mini-oral theatres near the exhibition. Each author will present a 4-slide PowerPoint orally for 4 minutes, followed by 3 minutes for discussion. Sessions will not be streamed but authors are invited to upload per-recordings for the online platform.

Overview: Poster Discussions are presented at one of the sessions scheduled at the two poster terminals in the exhibition. Each author will present a digital poster orally for 2 minutes, followed by 2 minutes for discussion. Sessions will not be streamed but authors are invited to upload per-recordings for the online platform.