E2RADIATE - EORTC-ESTRO Radiation Infrastructure for Europe

E2-RADIatE European Platform for Data Collection

Despite being very effective and widely used, radiation therapy still suffers from a lack of collective knowledge on how these treatments affect patients’ survival, func­tioning, symptoms and quality of life. Such information is available through the outcome of clinical trials, but formal data-sharing is rather haphazard, particularly where new treatments, techniques and technologies are involved.

With the advent of personalized cancer medicine, this means that patients may not always receive the most ef­fective treatment for their particular case. In a bid to put this situation to rights, ESTRO and EORTC have joined forces to launch a new initiative, E2-RADIatE.

E2-RADIatE is an infrastructure for research and data collection. It aims to support collaboration between ra­diation oncology professionals to generate robust data on the role of radiation therapy in cancer treatment and to further develop and integrate the discipline into ther­apeutic strategies.

E2-RADIatE will serve as an umbrella for multiple cohort studies that will prospectively collect real world data to support radiotherapy research. The first two cohorts within E2-RADIatE will be OligoCare and ParticleCare.

E²-RADIatE (1811)

  • Collection of real world data of patients treated with radiotherapy

  • Overarching infrastructure

  • Observational

  • Multi-cohort study *

  • One protocol

  • One informed consent

  • One database

* Cohort OligoCare (1822)

  • Radical radiotherapy for oligometastatic disease
  • Identify factors impacting overall survival
  • Patterns-of-care and patterns-of-outcome

* Cohort ParticleCare (1833)

  • Evaluation of particle therapy (protons/ions)

  • European Particle Therapy Network (EPTN)

* Future cohorts (TBD)

Study coordinators:

Yolande Lievens, Ghent University Hospital, Belgium Damien Weber, Paul Sherrer Institute Villigen, Switzerland