(1)TheraPanacea, Radiotherapy, Paris, France;(2)Department of Medical Physics, Gustave Roussy - Paris-Saclay University, Villejuif, France;(3)U1030 Molecular Radiotherapy, Paris-Sud University - Gustave Roussy - Inserm - Paris-Saclay University, Villejuif, France;(4)U1018 Radiation Epidemiology, Paris-Sud University - Gustave Roussy - Inserm - Paris-Saclay University, Villejuif, France;(5)Department of Radiotherapy, Gustave Roussy - Paris-Saclay University, Villejuif, France;(6)Centre de protonthérapie d’Orsay, Institut Curie - PSL Research University, Orsay, France;(7)U1021 Normal and Pathological Signaling: from the embryo to the innovative therapy of cancers, Institut Curie - Inserm - CNRS UMR 3347 - PSL Research University - Paris-Saclay University, Orsay, France;