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Overview: Vaginal cancer is a rare and challenging disease. To date there is no uniform European guidance for its optimal management with strong variations between the national and international guidelines. A multidisciplinary approach with coordinated collaboration between the different disciplines such as surgery, radiotherapy, medical oncology and pathology is key for optimal patients’ management. For those reasons the three major societies: ESTRO ESGO and SIOPE have worked together to develop and launch guidelines for this rare disease in adults and children/ adolescents in an effort to standardize and homogenise clinical care.