Copenhagen, Denmark
Onsite/Online

ESTRO 2022

Session Item

Monday
May 09
14:15 - 15:30
Auditorium 11
Adapting to changes on different time scales
Jasper Nijkamp, Denmark;
Ye Zhang, Switzerland
In this session we will start with Martin Fast, who will be discussion various real-time motion mitigation techniques to deal with periodic cardiorespiratory motion, including tracking, trailing, gating, and intra-fractional re-planning. Subsequently, Pierluigi Bonomo will discuss how do deal with unpredictable non-periodic target motion and deformation. He will discuss intrafraction GTV changes in rectal and prostate cancer, and how MR-guidance can be used to deal with these. In the third lecture Simon Skouboe will provide his insights into how real-time dose accumulation can be used to detect potential under- or over-dosing, and how act on these. In the last lecture, Stephen Bowen will give an overview of imaging biomarkers that can be used to predict or measure biological response to treatment, and how they can be used to adapt radiation therapy.
Symposium
Physics
15:09 - 15:27
Adapting to biological response based on quantitative imaging, peripheral blood, and tissue markers: Next-generation personalized radiation oncology
Stephen Bowen, USA
SP-0861

Abstract

Adapting to biological response based on quantitative imaging, peripheral blood, and tissue markers: Next-generation personalized radiation oncology
Authors:

Stephen Bowen1

1University of Washington, Radiation Oncology, Radiology (joint), Seattle, USA

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Abstract Text

Despite the growing arsenal of therapeutics for patients with advanced cancer, not all patients benefit from population-based treatment regimens. Quantitative imaging as a biomarker of biological response can be leveraged both for patient risk stratification and for spatially guided treatment adaptation / intensification. Peripheral blood biomarkers of the immune response and systemic disease burden can complement localized biological imaging assessments and tissue molecular diagnostics. This talk will present an overview of biological response-adaptive radiation therapy in clinical trials, comparing and contrasting different approaches. Ongoing investigations on the clinical utility of quantitative imaging and peripheral blood biomarkers as complements to tissue markers will be summarized in the context of emerging paradigms that seek to personalize radiation and immune modulating systemic therapy combinations.