ESTRO 2022

Session Item

Sunday

May 08

14:15 - 15:30

Auditorium 11

Ocular plaque brachytherapy

Chair: Frank-André Siebert, Germany;

Co-Chair: Michele Keane, Ireland

Overview: In three separate presentations, this symposium will address aspects of Ocular Plaque Brachytherapy in current clinical practice. The speakers will discuss a range of topics in relation to I-125 and Ru-106 radioisotopes, from their clinical application in the treatment of ocular carcinomas, to their relative Clinical Quality Assurance and treatment planning requirements. Radiobiological relevance with regard to clinical management and resultant treatment outcomes will also be considered. The recent GEC-ESTRO Survey on Ocular Plaque Brachytherapy, which serves to evaluate clinical practice using Ru-106 plaques, will also be presented and analysed in this symposium.

Session Type: Symposium

Track: Brachytherapy

Journey:

15:05 - 15:30

Clinical management and treatment outcomes of eye plaque treatment of uveal melanoma

Speaker: , Italy

Presentation Number: SP-0527

Abstract

Abstract Title:

Clinical management and treatment outcomes of eye plaque treatment of uveal melanoma

Authors:

Bruno Fionda¹, Luca Tagliaferri¹

¹Fondazione Policlinico Universitario A. Gemelli IRCCS, U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy

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Abstract Text

Uveal melanoma (UM) is by far the most common intra-ocular tumor in adults and derives from melanocytes. Historically, the initial therapeutic attempts to cure UM has been surgical removal of the eye, with clinically relevant consequences in terms of function, cosmesis, and psychological impact on patients. The Collaborative Ocular Melanoma Study (COMS) introduced the first uniform approach to perform interventional radiotherapy (IRT - brachytherapy) procedures in a standardized way which has allowed to confirm the equivalence of IRT with enucleation in terms of overall survival. Since the introduction of this important milestone, several international guidelines have been issued with regard to specific technical and procedural aspects, and it has allowed IRT to become the mainstream treatment worldwide. However, still nowadays, there is a lack of consensus about the main criteria to definitively assess UM response after IRT. We present a collection of paradigmatic cases treated at our institution and then discuss in detail the latest available evidence about radiological and clinical assessment of UM response after IRT.