Copenhagen, Denmark
Onsite/Online

ESTRO 2022

Session

Monday
May 09
14:15 - 15:30
Room D2
Lethal DNA double strand breaks production: Quality over quantity?
Marta Capala, The Netherlands;
Martin Pruschy, Switzerland
There is a growing interest in the radiotherapy community in utilizing high LET radiation due to its ability to induce complex DNA damage, especially double strand breaks (DSB), and consequently more efficiently kill tumor cells. However, what exactly the definition of “complex DSB” is and how it translates into an increased cell kill remains to be further elucidated. In this session both the modelling approach as well as experimental data will be presented that bring us closer to answering those questions, by adding to our understanding of the generation of complex DSBs and their interplay with the cell genetic background and DBS repair mechanisms. Future directions for translating these fundamental insights into an increased radiotherapy efficacy will be highlighted in the last talk of the session.
3320
Symposium
Interdisciplinary
14:15 - 14:40
Stephen McMahon, United Kingdom
SP-0840
14:40 - 15:05
George Iliakis, Germany
SP-0841
15:05 - 15:30
Anthony Chalmers, United Kingdom
SP-0842