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Copenhagen, Denmark
Onsite/Online

ESTRO 2022

Session Item

Brachytherapy: Urology (prostate, bladder, penile)
7020
Poster (digital)
Brachytherapy
mpRMI-guided transperineal prostate biopsy: analysis of PIRADS and Gleason result
María Herrera Román, Spain
PO-1814

Abstract

mpRMI-guided transperineal prostate biopsy: analysis of PIRADS and Gleason result
Authors:

María Herrera Román1, María Sánchez Belda1, Patricia Valencia Nieto1, David Miguel Pérez1, Pilar Alonso Martínez1, Jesús María de Frutos Baraja1, Ignacio Solís Navarro1, Laura Cardoso Rubio1, Ana Casado Camacho2, Rocío Jaraiz Díaz1, Laura Rodríguez Mínguez1, María Gabriela Morgade Yllera1, Daniel Rodríguez Domínguez3, Patricia Diezhandino García1

1Hospital Clínico Universitario de Valladolid, Radiation Oncology, Valladolid, Spain; 2Hospital Clínico Universitario de Valladolid, Radiation Oncology, Valadolid, Spain; 3Hospital Clínico Universitario de Valladolid, Radiation oncology, Valladolid, Spain

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Purpose or Objective

To assess the relationship between PIRADS in multiparametric magnetic resonance imaging (mpMRI) and the Gleason result in a sample of 69 patients using mpMRI-guided transperineal prostate biopsy in the diagnosis of prostate cancer.

Material and Methods

Retrospective descriptive study of 69 patients who underwent biopsy in 2020, with a total of 91 suspects nodules to be analyzed, PSA between 2.68 and 26.9 ng/ml and suspicious mpMRI. Retrospective descriptive study of 69 patients, with a total of 91 suspicious nodules to be analyzed, PSA between 2.68 and 26.9 ng / ml and suspicious multiparametric MRI.

Estudio descriptivo retrospectivo de 69 pacientes, con un total de 91 nódulos sospechosos a analizar, PSA entre 2,68 y 26,9 ng / ml y RM multiparamétrica sospechosa.

Retrospective study of 69 patients description, a total of 91 suspicious nodules analyzed, PSA between 2.68 and 26.9 ng / ml and multiparameter NMR suspicious.

Estudio retrospectivo de descripción de 69 pacientes, analizados un total de 91 nódulos sospechosos, PSA entre 2,68 y 26,9 ng / ml y RMN multiparamétrica sospechosa.

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A transperineal biopsy guided by transrectal ultrasound with fusion-mpMRI was performed.

Results

91 nodules were analyzed. 43 (47.78%) had a positive result for malignancy, 43 (47.78%) had a negative result, 4 (4.44%) had a negative result for malignancy, with high-grade prostatic intraepithelial neoplasia (PIN).
Results of 16 PIRADS-3 nodules: Gleason 6 (3+3) 4 nodules (25%), negative in 12 nodules (75%).

Results of 61 PIRADS-4 nodules: Gleason 6 (3+3) 6 nodules (6%), Gleason 7 (3+4) 10 nodules (16.39%), Gleason 7 (4+3) 13 nodules (21.31%), negative  32 nodules (52.46%).

Results of 14 PIRADS-5 nodules: Gleason 6 (3+3) 1 nodule (7.14%), Gleason 7 (3+4) 4 nodules (28.57%), Gleason 7 (4+3) 5 nodules (35.71%), Gleason 9 (4+5) 1 nodule (7.14%), negative 3 (21.43%).

Conclusion

In this study, the relationship between PIRADS and the pathological result is observed, so that, as the degree of radiological suspicion increases (PIRADS), the aggressiveness result (Gleason grade) is more significant.

The ultrasound-guided biopsy with fusion with mpMRI allows directing the biopsy to the suspicious nodule and thus, increasing the sample's profitability, therefore, the most efficient technique in patients with a high radiological suspicion of prostate cancer.