Cerenkov free micro-dosimetry in the radiation therapy treatment
Sree Bash Chandra Debnath,
France
PO-1568
Abstract
Cerenkov free micro-dosimetry in the radiation therapy treatment
Authors: Sree Bash Chandra Debnath1, Carole FAUQUET1, Marjorie Ferre2, Agnes Tallet3, Anthony Goncalves2,4, Didier Tonneau1, Julien Darreon5
1Aix Marseille Université, Centre Interdisciplinaire de Nanoscience de Marseille - CINaM -UMR 7325, Marseille, France; 2Institut Paoli-Calmettes, Department of Radiotherapy, Marseille, France; 3Institut Paoli-Calmettes, Department of Radiotherapy, Marseille, France; 4Aix Marseille Université, CNRS UMR 7258, INSERM UMR 1068, CRCM, Marseille, France; 5Institut Paoli-Calmettes, Department of Radiotherapy , Marseille, France
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Purpose or Objective
Optical fiber-based scintillating dosimetry is the most recent promising
technique due to the miniature size dosimeter and improve quality assurance in modern
radiation therapy. Despite several advantages, the major issue of using
scintillating dosimeters is the Cerenkov Effect and predominantly requires
extra measurement correction factors. Therefore, this work highlighted a novel micro-dosimetry
technique to ensure Cerenkov-free measurement and provide quality treatment.
Material and Methods
A micro-dosimetry technique was proposed with the performance evaluation
of a novel infrared inorganic scintillator detector (IR-ISD). The detector
essentially consists of a micro-scintillating head with a sensitive volume of
1.5x10-6 mm3. The proposed system was evaluated under the
6/15 MV LINAC beam as well as 320KV- 192Ir Brachytherapy (BT) source
used in the patient treatment system. Overall measurements were performed using
IBATM water tank phantoms by following TRS-398 protocol for
radiotherapy and TG43U1 recommendations for BT. Cerenkov measurements were
performed for different small fields from 0.5x0.5 cm2 to 10x10cm2
under LINAC as well as till 0.25cm distance from the BT source. In addition, several
dosimetric parameters such as PDD, beam profiling, dose linearity, dose rate
linearity, repeatability, and scintillation stability were investigated to realize
the device’s performance. Finally, a comparative study will be shown using
Monte-Carlo (MC) simulation, and data from recent literature.
Results
This study highlighted a complete
removal of the Cerenkov Effect using a point-like miniature detector,
especially for small field radiation beam treatment. Measurements
demonstrated that IR-ISD has acceptable behavior with dose rate variability
(maximum standard deviation ~ 0.15%) for the dose rate of 20 cGy/s to 1000
cGy/s. An entire linear response (R2=1) was obtained with the
dose delivered in the range of 4cGy to 1000 cGy, independently of the field
size selected from 4 x 4 cm² to 0.5 x 0.5 cm². Perfect repeatability
(0.15 % variation from average) with day-to-day reproducibility (0.25%
variation) was observed. PDD profiles obtained in the water tank present
identical behavior to the reference dosimeter with a build-up maximum depth
dose at 1.5 cm. The small field of 0.5 x 0.5 cm² profiles have been
characterized to determine convolution and penumbra effect. Eventually, in
BT, a comparison with MC simulations shows that measurement agrees within 0.65%
till 0.25 cm source-to-detector distance.
Conclusion
Unlike recent advanced PSD systems
(e.g., exradin W1/W2), the proposed micro-dosimetry system in this study requires
no Cerenkov corrections and showed efficient performance for several dosimetric
parameters. Therefore, it is expected that the IR-ISD system can be promoted to
validate with direct clinical investigations, such as in the small-field dose verification,
intra-beam characterizations, and BT treatment plan.