LATTICE radiotherapy: A one institution experience
PO-1468
Abstract
LATTICE radiotherapy: A one institution experience
Authors: Jorge Germain1, Aura Ciafre1, Oriana Prato1, Isaac Solero1, Maria Borras1, Francisco Celada1, Natalia Tejedor2, Gimeno Jose2
1Hospital Universitari i Politècnic La Fe, Radiation Oncology, Valencia, Spain; 2Hospital Universitari i Politècnic La Fe, Radiation Oncology (Physics), Valencia, Spain
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Purpose or Objective
LATTICE
Radiotherapy (LRT) emerges as an innovative approach for treatment of
voluminous tumors not suitable for resection. We aim to evaluate the
tumor response and safety of this technique in a cohort of patients with bulky
tumors treated in our institution.
Material and Methods
A retrospective review of patients treated with LTR from January 2019 to
June 2021 has been analyzed. Patients and treatment characteristics are shown
on table 1. VMAT plans were employed in all cases and treatments were guided by
CBCT on each fraction. RTOG scales of toxicity have been employed.
Results
12
patients with median age of 50 years (42 to 81) were found to receive LTR. The
tumor volume ranged from 310cc to 2511cc with a median of 5 lattice vertices (2
to 13) placed within the GTV representing a median of 0,8% of its volume. Lung
tumor was the most frequent site (41,6%). 3 patients received a total dose
(EQD2) >60Gy. Image evaluation post LRT was performed in 5 patients, showing
volume reduction in all cases. With a median follow up of 3 months (2 to 27) no
mortality or toxicity Grade 2-3 related to LTR was found.
Conclusion
LTR
appears to be a safe modality to treat bulky tumors without significant
morbidity directly related to RT treatment. Further develop of treatment
protocols to standardize LTR are required.