Radiosurgery in brain metastases: prognostic scales
PO-1148
Abstract
Radiosurgery in brain metastases: prognostic scales
Authors: Abrahams Ocanto1, Raúl Matute2, Ana Castaño2, Beatriz Debén2, Marta Rodríguez2, Isabel Garrido2, Macarena Teja2, Mercedes González2, Rosa Morera2
1University Hospital La Paz, Radiation Oncology, Madrid, Spain; 2Universitary Hospital La Paz, Radiation Oncology, Madrid, Spain
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Purpose or Objective
To evaluate retrospectively the utility of the Score Index for Radiosurgery (SIR) and the Graded Prognostic Assessment (GPA) in predicting survival in patients with brain metastases treated with radiosurgery (SRS).
Material and Methods
51 patients treated with radiosurgery (single fraction and multifraction) in Universitary Hospital La Paz in Madrid, Spain from 2015 to 2020 were included in the study. They were classified according to the result of the SIR and GPA, given by the variables: age, Karnofsky Performance Status (KPS), systemic disease, number of metastases and largest lesion volume. The GPA was obtained through summation of the previously noted first four prognostic factors and SIR five prognostic factors.
Results
The median age were 65,17 +/- 7,32 (47-78). 53% male and 47% female, 25,5% received SRS single fraction (16 and 18Gy) and 74,5% received SRS multifraction (25, 27 and 30Gy). The Kaplan–Meier method together with log rank was used to estimate and test correlation between survival and all prognostic factors. We found with GPA for each unit that the index increases, mortality is reduced by 49,9% and for each unit that the SIR increases, mortality is reduced by 22,6% (p=0,001).
Conclusion
SIR and GPA is a reliable prognostic score for cancer patients with brain metastases submitting to radiosurgery. This index should be tested for larger series.