In vivo dosimetry: Optical fibre characterisation for use in adaptive HDR pelvic brachytherapy
Orla Houlihan,
United Kingdom
PD-0813
Abstract
In vivo dosimetry: Optical fibre characterisation for use in adaptive HDR pelvic brachytherapy
Authors: Orla Houlihan1,2, Emma Marlow2, Sergio Esteve3, Geraldine Workman3, Monica Byrne3, Conor McGarry3, Mark Grattan3, Sinead O'Keeffe4, Kevin Prise2, Alan Hounsell3,5, Suneil Jain1,5
1Northern Ireland Cancer Centre, Belfast City Hospital, Clinical Oncology, Belfast, United Kingdom; 2Queen's University Belfast, Patrick G. Johnston Centre for Cancer Research, Belfast, United Kingdom; 3Northern Ireland Cancer Centre, Belfast City Hospital, Radiotherapy Medical Physics, Belfast, United Kingdom; 4Optical Fibre Sensors Research Centre, University of Limerick, Department of Electronic and Computer Engineering, Limerick, Ireland; 5Queen’s University Belfast, Patrick G. Johnston Centre for Cancer Research, Belfast, United Kingdom
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Purpose or Objective
To
characterise and calibrate 1 mm core PMMA optical fibre sensors as a first step
in the integration of optical fibre sensors, developed as part of the EU funded
H2020 project “ORIGIN”, within HDR pelvic brachytherapy for use in adaptive
brachytherapy.
Material and Methods
An
optical fibre connected to a scintillation detector of 0.5 mm radius was used
to undertake measurements on an Elekta Flexitron HDR system. Initial
measurements were performed by placing the fibre within a HDR prostate Perspex needle
phantom capable of holding 20 HDR needles in parallel, placed between two solid
water blocks. The fibre was placed within a plastic HDR needle inserted in a
channel 2 cm from the Iridium-192 source within the phantom, for a dwell time
of 35 seconds (Fig. 1(a) and 1(b)). Measurements were performed three times
without removing either the fibre or the source from the setup to assess
repeatability.
The
fibres were then placed in a water tank jig at 1 cm intervals, with positioning
supported between the lid of the tank and a support bridge within the water(Fig.
2(a) and 2(b)) The Perspex support bridge was built within the tank to anchor
the distal end of the brachytherapy needles containing the fibre and source,
ensuring vertical placement within the jig. The distance from the lid of the water tank to the support bridge was
approximately 15 cm to simulate full scatter conditions with water. The output of the fibres was assessed using an 192Ir
radioactive source for a dwell time of 15 seconds and compared with estimated
outputs from the treatment planning system (TPS).
Results
The
repeatability measurements of the optical fibre within the Perspex needle
phantom demonstrated variation of less than 1% (Fig. 1(c)). The output signal, as
the source-to-sensor distance is increased in 1 cm increments from 1 cm to 10
cm is shown in Fig. 2(c). As expected, given the inverse square law, a large
drop in the optical signal was observed for measurements closest to the source,
with a slower taper at greater distances. The relative difference between the
output of the optical fibre and that of the TPS increased significantly with
increasing distance, due to the fibre sensor’s energy-dependence, and a correction factor must be
determined to reduce this deviation (Fig. 2(c)).
Conclusion
The
optical fibre sensors demonstrated reproducible measurements with the need for
a correction factor to be applied to account for differences in the fibre output
and TPS output. Angular and temperature dependence need to be assessed to
determine appropriate correction factors. Calibration of the fibres with a well
chamber will be performed via intercomparison with a Farmer chamber, following
which the fibres will be tested in anthropomorphic phantoms prior to clinical
testing.