Six patients referred to HYPO (42.7 Gy in 7
fractions) prostate MRI-only radiotherapy were included in the analysis. One
large field of view T2 weighted sequence (T2 cli), for synthetic CT
(sCT) generation and consequently treatment planning, was acquired for each
patient using coil bridges according to clinical routine. The coil bridge was then
removed, and the air coil was placed directly on the patient. A second identical
T2 was added to the examination (T2ncb). A 3T GE scanner, large anterior
air coil and a posterior built-in spine coil were used for all acquisitions.
Anatomical difference between the T2cli
and T2ncb was assessed to evaluate potential deformation from the on-patient
air coil placement by measuring the absolute maximum anterior-posterior thickness
(AMT) of the patient in the same left-right position on a slice in the middle
of the prostate.
The T2cli and T2ncb were
used to generate sCTs (sCTcli and sCTncb). The clinically
approved treatment plan, created on sCTcli, was transferred and
recalculated on the 6D rigidly registered sCTncb, using the same
number of monitor units. The clinical dose metrics for the mean PTV dose, rectum
V96%, V89% and V77%, and mean bladder dose
were analysed using the clinical structure set. A paired Wilcoxon signed-rank
test was used for dose metric comparisons, p < 0.05 was considered
statistically significant.
The SNR using coil bridges was measured in a
homogenous phantom where the air coil and bridge was placed at a 5, 10, 15 and
20 cm distance from the surface of the phantom.