Therapy-shaping of the tumour microenvironment: How does the tumour-host immune cells interactions affect radiotherapy outcome?
Michele Mondini,
France;
Zuzanna Nowicka,
Poland
This session will explore the complex interplay between radiotherapy (RT) and the tumor microenvironment (TME), focusing on stromal-mediated immunosuppression, metabolic rewiring, and immune escape mechanisms. Key topics include the role of cancer-associated fibroblasts (CAFs), tumor associated macrophages (TAMs) and tumor infiltrating lymphocytes (TILs) in promoting radio-sensitivity vs resistance, the impact of RT on the tumor stroma, TME reshaping by low-dose RT (LDRT), and strategies to enhance radio-immunotherapy synergy including by targeting metabolic enzymes. Additionally, speakers will explore the role of hypoxia, particularly in glioblastoma, and of dysregulated purinergic signaling in radiation-induced immune escape.
Symposium
Radiobiology