Glasgow, United Kingdom

ESTRO 2024

Session

Sunday
May 05
08:45 - 10:00
Boisdale
Single cell and spatial radiation biology: From cancer to normal tissue response
Ananya Choudhury, United Kingdom;
Bartłomiej Tomasik, Poland
This session delves into the intricate landscape of cancer heterogeneity, where the dynamic interplay of diverse tumour cell states dictate treatment response and toxicity. We will discuss in vitro and in vivo preclinical models used to investigate the molecular effects of radiation. Our expert panel will describe the use of transcriptomics and innovative single-cell techniques to explore therapeutic strategies targeting tumour plasticity, how focal radiation induces distinct intestinal regeneration patterns compared to whole abdomen irradiation, and the role of Notch-signalling in preserving stemness with proton therapy. The presentations aim to bridge the gap between preclinical models and clinical applications, with a focus on enhancing patient care through precision medicine.
2090
Symposium
Radiobiology
08:45 - 09:03
Cell-state dynamics regulate the sensitivity of tumours to radiotherapy
Mohamed Abazeed, USA
09:03 - 09:21
Single-cell transcriptomics on salivary gland organoids after photon and proton radiotherapy
Rob Coppes, The Netherlands
09:21 - 09:39
Emerging perspectives on intestinal stem cell regeneration through single-cell and spatial analysis
Ioannis (Yiannis) Verginadis, USA
09:39 - 09:57
Single-cell analysis of lung responses to radiation injury
Charles Fouillade, France