Session

Overview: Radiation-induced senescent cells may provide a microenvironment that facilitates tumor growth and recurrence. New strategies are currently emerging aimed at improving radiotherapy by eliminating the negative effects of senescent cells. The symposium will cover: 1) intrinsic and extrinsic factors determining senescence-associated phenotypes, 2) senolytic and senomorphic strategies to interfere with therapy-induced senescent cells, 3) senescence and other effects of radiation on cancer-associated fibroblasts (CAFs) derived from lung and head and neck cancers, 4) radiation-induced changes in the immunomodulatory effects of CAFs, and 5) glioblastoma recurrence driven by radiotherapy-induced senescence of tumor and normal brain cells.