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The diagnosis of gynecological cancer (cervix and endometrium cancer) and the subsequent treatments such as interventional radiotherapy (IRT, also called brachytherapy) may result in emotional anxiety and distress, which may have an impact on the clinical outcome. High levels of anxiety prior to starting RT are reported in about 10- 20% of patients. At the time of simulation and IRT delivery, anxiety is commonly expressed as a result of immobilization techniques, of isolation in a room, altogether associated with their own problems and fear of cancer. In this scenario, multidisciplinary and multiprofessional approaches are necessary to ensure that patients will be adequately informed about treatment but also to obtain their inner serenity. For this reason, recently, several studies have focused on gynecologic cancer survivors and the information needs of this population. Particularly, in our department we examined the needs of patients affected by gynecological cancer focusing on physician–patient communication and treatment approach, as well as on the need for information concerning therapy effectiveness, side effects, toxicities and consequences. Aim of my presentation is to describe our patient-centered approach in IRT, based on psychological evidence-based interventions,  integrating technologies and human relationship.