106 patients treated with HF and 157 patients treated with CF were included. Median follow-up in the HF and the CF group was 12 and 57 months, respectively. Regarding acute GI toxicity, grade 0 was reported in 13.3 % (HF) vs. 6.4 % (CF), grade 1 in 40.0 % vs. 54.8 %, grade 2 in 46.7 % vs. 37.6 % and grade 3 in 0 % vs. 1.3 % showing no significant difference (p = 0.71). Regarding acute GU toxicity, grade 0 was reported in 20 % (HF) vs. 10.8 % (CF), grade 1 in 57.1 % vs. 57.3 %, grade 2 in 20.0 % vs. 31.8 %, and grade 3 in 2.9 % vs. 0 %, showing a significant difference in favor of HF (p = 0.04). The maximal rate of late GI toxicity was grade 0 in 76.4 % (HF) vs. 61.8 % (CF), grade 1 in 16.0 % vs. 21.7 %, grade 2 4.7 % vs. 13.8 %, and grade 3 1.9 % vs. 2.6 %. The maximum rate of late GU toxicity was grade 0 in 62.3 % (HF) vs. 45.4 % (CF), grade 1 in 26.4 % vs. 26.3 %, grade 2 in 11.3 % vs. 23.0 %, and grade 3 0 % vs. 5.3 %. However, as follow-up time differs between both groups, we compared late GI and GU toxicity between both groups after 3, 12, and 24 months and did not find any significant differences (p = 0.59, 0.22 and 0.71 for GI toxicity and 0.39, 0.58, and 0.90 for GU, respectively).
Table 1: Maximum Acute Gastrointestinal and Genitourinary Toxicity after moderate hypofractionation (HF) and conventional fractionation (CF).
Acute Toxicity
| Gastrointestinal
|
| Genitourinary
|
|
| HF
| CF
| HF
| CF
|
RTOG grade 4
| 0.0 %
| 0.0 %
| 0.0 %
| 0.0 %
|
RTOG grade 3
| 0.0 %
| 1.3 %
| 2.9 %
| 0.0 %
|
RTOG grade 2
| 46.7 %
| 37.6 %
| 20.0 %
| 31.8 %
|
RTOG grade 1
| 40.0 %
| 54.8 %
| 57.1 %
| 57.3 %
|
RTOG grade 0
| 13.3 %
| 6.4 %
| 20.0 %
| 10.8 %
|
P = 0.71 and 0.04 for gastrointestinal and genitourinary toxicity, respectively. N = 105 for HF and 157 for CF