The research projects that I develop with my team have a primary goal of discovering innovative tools able to protect normal tissue and enhance tumor control. One significant accomplishment has been the development of a groundbreaking radiation therapy technique called FLASH-Radiotherapy, which offers to reduce normal tissue toxicity and eradicates tumors in various organs including the brain, lung and skin. We have successfully tested this new approach of RT on various species, including mice, zebrafish, mini-pigs, and cats. Our efforts have primarily focused on exploring the distinct biological reactions triggered by FLASH exposure on normal tissue and tumors and recently we found that FLASH could overcome radiation resistance. A crucial aspect of our work involves ensuring the advancement of FLASH-RT into safe and meaningful clinical trials for human cancer patients.