Inter-correlations between various high-risk pathological factors in squamous cell carcinoma tongue
PO-1028
Abstract
Inter-correlations between various high-risk pathological factors in squamous cell carcinoma tongue
Authors: Parveen Ahlawat1, Athira Krishnan1, Munish Gairola1, Sarthak Tandon1, Sandeep Purohit1, Nishtha Sachdeva1, Muhammed Ismail Sharief1, Kiran Dobriyal1, Tulika Singh1
1Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Radiation Oncology, New Delhi, India
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Purpose or Objective
While exploring histopathological
high-risk factors for squamous cell carcinoma of oral cavity most studies have included
mixed population of oral cavity subsites such as oral tongue, buccal mucosa,
retromolar trigone, gingivo-buccal sulcus, floor of mouth, hard palate and
alveolus. Oral tongue have different natural history and hence may behave
differently from other sites with regard to high-risk pathological factors. The
objective of this study was to explore inter-correlations
between various pathological high-risk factors found in resected specimen of OTSCC.
Material and Methods
It was a retrospective analysis in which we reviewed the final
histopathology of surgical specimen of 202 patients with OTSCC who had
undergone upfront surgical resection followed by adjuvant therapy.
Inter-correlations were performed between various pathological factors using
Spearman’s correlation test. Factors assessed were pathological T stage, pathological nodal stage (N Stage),
lymphovascular invasion (LVI), perineural invasion (PNI), depth of invasion
(DOI), tumour thickness (TT), worst pattern of invasion (WPOI), and extranodal
extension (ENE).
Results
Various inter-correlation between factors
found are shown in Table.
Factors
| pT Stage
| pN Stage
| DOI
| Grade
| PNI
| LVI
| TT
| WPOI
| ENE
|
pT Stage
| -
| Yes
| Yes
| No
| Yes
| No
| Yes
| No
| Yes
|
pN Stage
| Yes
| -
| No
| No
| Yes
| Yes
| Yes
| Yes
| Yes
|
Grade
| No
| No
| No
| -
| No
| No
| No
| Yes
| No
|
PNI
| Yes
| Yes
| Yes
| No
| -
| Yes
| Yes
| Yes
| Yes
|
LVI
| Yes
| Yes
| Yes
| No
| Yes
| -
| Yes
| Yes
| Yes
|
DOI
| Yes
| No
| -
| No
| Yes
| No
| Yes
| No
| No
|
TT
| Yes
| No
| Yes
| No
| Yes
| Yes
| -
| Yes
| Yes
|
WPOI
| Yes
| Yes
| Yes
| No
| Yes
| Yes
| No
| -
| Yes
|
ENE
| Yes
| Yes
| No
| No
| Yes
| Yes
| No
| No
| -
|
Conclusion
pT stage has significant positive correlation
with pN stage, DOI, PNI, TT and ENE. pN stage has significant positive
correlation with PNI, LVI, TT, WPOI and ENE. Grade has significant correlation
with WPOI. PNI has significant correlation with DOI, LVI, TT, WPOI and ENE. LVI
has significant correlation with pT stage, DOI, PNI, TT, WPOI and ENE. DOI has
significant correlation with pT stage, PNI and TT. TT has significant
correlation with pT stage, DOI, PNI, LVI, WPOI and ENE. WPOI has significant
correlation with pT stage, pN stage, DOI, PNI and LVI. ENE has significant
correlation with pT stage, pN stage, PNI and LVI. Many of these correlations
are not shown in most other studies on oral cancer.