By the end of this course participants should be able to:
- Describe the rationale and mechanisms of the action of combined drug radiation treatment in cancer
- Discuss the evidence for combined drug radiation treatment in different tumour sites
- Select patients for combined drug radiation treatment
- Decide on the optimum treatment strategy, sequencing and duration, for different patients
- Decide on the optimum strategy including new drugs (immunotherapy etc.).
COURSE CONTENTGeneral lectures
- Biologic basis for combining drugs with radiation
- Combining drugs with radiation: quantifying the therapeutic gain
- Combining new drugs with radiotherapy
- Radiation and non-cytotoxic drugs
- Hypoxic cell radiosensitisers
- Alteration of radiotherapy fractionation and concurrent chemotherapy
- Designing clinical trials for combined modality treatments.
Site specific lectures including practical case discussions
- Head and neck cancer
- Non small cell lung cancer
- Small cell lung cancer
- Breast cancer
- Prostate cancer
- Bladder cancer
- Cervical cancer
- Oesophageal cancer
- Gastric cancer
- Rectal cancer
- Anal canal
- Brain tumours
Before commencing this course participants should:
- Be confident with the basic mechanisms of radiotherapy and systemic treatment in oncology
- Know the basic principles of management of solid tumours
- Know different ways of delivering chemotherapy/systemic therapy in combination with radiotherapy.
- 20 hours of lectures
- 5 hours of case discussions
- Presentation and critical discussion of the available evidence, discussion of clinical cases.
METHODS OF ASSESSMENT
- Evaluation form.