LEARNING OUTCOMES

By the end of this course participants should be able to:

  • Describe the rationale and mechanisms of the action of combined drug radiation treat­ment in cancer
  • Discuss the evidence for combined drug ra­diation treatment in different tumour sites
  • Select patients for combined drug radiation treatment
  • Decide on the optimum treatment strategy, sequencing and duration, for different patients
  • Decide on the optimum strategy including new drugs (immunotherapy etc.).

 

COURSE CONTENT

General lectures
  • Biologic basis for combining drugs with radiation
  • Combining drugs with radiation: quantifying the therapeutic gain
  • Combining new drugs with radiotherapy
  • Radiation and non-cytotoxic drugs
  • Hypoxic cell radiosensitisers
  • Alteration of radiotherapy fractionation and concurrent chemotherapy
  • Designing clinical trials for combined modality treatments.

Site specific lectures including practical case discussions

  • Head and neck cancer
  • Non small cell lung cancer
  • Small cell lung cancer
  • Breast cancer
  • Prostate cancer
  • Bladder cancer
  • Cervical cancer
  • Oesophageal cancer
  • Gastric cancer
  • Rectal cancer
  • Anal canal
  • Pancreas
  • Brain tumours
  • Lymphomas.

PREREQUISITES

Before commencing this course participants should:

  • Be confident with the basic mechanisms of radiotherapy and systemic treatment in oncology
  • Know the basic principles of management of solid tumours
  • Know different ways of delivering chemotherapy/systemic therapy in combination with radiotherapy.

TEACHING METHODS

  • 20 hours of lectures
  • 5 hours of case discussions
  • Presentation and critical discussion of the available evidence, discussion of clinical cases.

METHODS OF ASSESSMENT

  • MCQ
  • Evaluation form.